Iimvavanyo zeklinikhi

Kwakungekho ama-induration amatsha aqatshelwe kwiqela le-NIF xa kuthelekiswa ne-IP. (P = 0.0150) Inaliti ephukileyo yabonwa kwiqela le-IP, akukho mngcipheko kwiqela le-NIF.Ukunciphisa intsingiselo ehlengahlengisiweyo ukusuka kwisiseko se-HbA1c 0.55% ngeveki ye-16 kwiqela le-NFI lalingekho ngaphantsi kwaye liphezulu ngokwezibalo xa lithelekiswa nelo le-0.26% kwiqela le-IP.Ukulawulwa kwe-insulin nge-NIF kunokubonelela ngeprofayili yokhuseleko olungcono kune-injection ye-IP, ngokunciphisa imikrwelo yesikhumba, i-induration, intlungu kwaye akukho mngcipheko weenaliti eziphukileyo.

Intshayelelo:

Umyinge wezigulana ezinesifo seswekile sohlobo lwesi-2 usebenzisa i-insulin usephantsi kakhulu kwaye uhlala uqalwa emva kwexesha.Izinto ezininzi zifunyenwe zichaphazela ukulibaziseka kokusetyenziswa kwe-insulin, kubandakanywa ukwesaba iinaliti, ukuphazamiseka kwengqondo ngexesha lokutofa kwe-insulin kunye nokuphazamiseka kwe-insulin injection, zonke ezo zizathu ezibalulekileyo zezigulane ezingafuni ukuqalisa unyango lwe-insulin.Ukongeza, ingxaki yenaliti efana ne-induration ebangelwa kukusetyenziswa kwakhona kwenaliti ixesha elide inokuchaphazela ukusebenza konyango lwe-insulin kwizigulana esele zisebenzise i-insulin.

Isitofu se-insulin esingenanaliti senzelwe izigulane ezinesifo seswekile ezoyika iinaliti okanye ezithandabuzayo ukuqalisa unyango lwe-insulin xa luchazwe ngokucacileyo.Olu pho nonongo lujolise ekuvavanyeni ukwaneliseka kwesigulane kunye nokuthotyelwa kwe-insulin injector engenanaliti ngokubhekiselele kwi-insulin yesiqhelo yokujova ipeni kwizigulane ezine-T2DM eziphathwa kwiiveki ze-16.

Iindlela:

I-totali yezigulane ze-427 ezine-T2DM zibhaliswe kwi-multi-center, i-prospective, i-randomized, i-open-label study, kwaye i-randomized 1: i-1 yokufumana i-insulin ye-basal okanye i-insulin exutywe ngaphambili nge-injector engenanaliti okanye nge-injection ye-insulin yesiqhelo.

Isiphumo:

Kwizigulane ze-412 eziye zagqiba isifundo, amanqaku e-questionnaire athetha ukuba i-SF-36 yanda kakhulu kwi-injector engenanaliti kunye namaqela aqhelekileyo epeni ye-insulin, kungekho ntlukwano ebalulekileyo phakathi kwamaqela ngokuthobela.Nangona kunjalo, izifundo kwiqela le-injector elingenanaliti libonise amanqaku okwaneliseka aphezulu kakhulu kunalawo akwiqela le-insulin yesiqhelo emva kweeveki ze-16 zonyango.

Isishwankathelo:

Akukho mahluko ubalulekileyo phakathi kwepeni ye-insulin kunye namaqela enaliti engenanaliti kwesi siphumo se-SF-36.

Inaliti engenanaliti ye-insulin ikhokelela ekwanelisekeni okuphezulu kwesigulana kunye nokuthotyelwa konyango oluphuculweyo.

Isiphelo:

Isitofu esingenanaliti siphucule umgangatho wobomi bezigulana ze-T2DM kwaye kwaphucula kakhulu ukwaneliseka kwabo ngonyango lwe-insulin xa kuthelekiswa nenaliti yepeni ye-insulin eqhelekileyo.